Mu opioid receptors inhibit GABA release from parvalbumin interneuron terminals onto CA1 pyramidal cells

Caifeng Shao; Pei Chen; Qian Chen; Mingwei Zhao; Wei Ning Zhang; Kun Yang

doi:10.1016/j.bbrc.2019.12.013

Mu opioid receptors inhibit GABA release from parvalbumin interneuron terminals onto CA1 pyramidal cells

Caifeng Shao
, Pei Chen
, Qian Chen
, Mingwei Zhao
, Wei Ning Zhang
, Kun Yang

Nantong Hospital of Traditional Chinese Medicine
Jiangsu University
University of Maryland, Baltimore

科研成果: 期刊稿件 › 文章 › 同行评审

11 引用（Scopus）

摘要

Selectively activating (by optogenetics) parvalbumin-expressing (PV) interneurons induces GABA release onto CA1 pyramidal cells. Here we report that this release was attenuated by presynaptic mu opioid receptors (MORs) activation. On the other hand, conventional electric shock, presumably activating non-selectively presynaptic GABAergic terminals, also induced GABA release; however, this release showed relatively limited depression by MORs activation. The data suggest that MORs specifically inhibit GABA release from PV terminals and therefore, further support the idea that MORs contribute to homeostasis in CA1 neuro-circuit.

源语言	英语
页（从-至）	1059-1062
页数	4
期刊	Biochemical and Biophysical Research Communications
卷	522
期	4
DOI	https://doi.org/10.1016/j.bbrc.2019.12.013
出版状态	已出版 - 19 2月 2020
已对外发布	是

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10.1016/j.bbrc.2019.12.013

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title = "Mu opioid receptors inhibit GABA release from parvalbumin interneuron terminals onto CA1 pyramidal cells",

abstract = "Selectively activating (by optogenetics) parvalbumin-expressing (PV) interneurons induces GABA release onto CA1 pyramidal cells. Here we report that this release was attenuated by presynaptic mu opioid receptors (MORs) activation. On the other hand, conventional electric shock, presumably activating non-selectively presynaptic GABAergic terminals, also induced GABA release; however, this release showed relatively limited depression by MORs activation. The data suggest that MORs specifically inhibit GABA release from PV terminals and therefore, further support the idea that MORs contribute to homeostasis in CA1 neuro-circuit.",

keywords = "GABA, Hippocampus, Mu opioid receptors, Optogenetics, Parvalbumin, Whole-cell recordings",

author = "Caifeng Shao and Pei Chen and Qian Chen and Mingwei Zhao and Zhang, \{Wei Ning\} and Kun Yang",

note = "Publisher Copyright: {\textcopyright} 2019 Elsevier Inc.",

year = "2020",

month = feb,

day = "19",

doi = "10.1016/j.bbrc.2019.12.013",

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TY - JOUR

T1 - Mu opioid receptors inhibit GABA release from parvalbumin interneuron terminals onto CA1 pyramidal cells

AU - Shao, Caifeng

AU - Chen, Pei

AU - Chen, Qian

AU - Zhao, Mingwei

AU - Zhang, Wei Ning

AU - Yang, Kun

PY - 2020/2/19

Y1 - 2020/2/19

N2 - Selectively activating (by optogenetics) parvalbumin-expressing (PV) interneurons induces GABA release onto CA1 pyramidal cells. Here we report that this release was attenuated by presynaptic mu opioid receptors (MORs) activation. On the other hand, conventional electric shock, presumably activating non-selectively presynaptic GABAergic terminals, also induced GABA release; however, this release showed relatively limited depression by MORs activation. The data suggest that MORs specifically inhibit GABA release from PV terminals and therefore, further support the idea that MORs contribute to homeostasis in CA1 neuro-circuit.

AB - Selectively activating (by optogenetics) parvalbumin-expressing (PV) interneurons induces GABA release onto CA1 pyramidal cells. Here we report that this release was attenuated by presynaptic mu opioid receptors (MORs) activation. On the other hand, conventional electric shock, presumably activating non-selectively presynaptic GABAergic terminals, also induced GABA release; however, this release showed relatively limited depression by MORs activation. The data suggest that MORs specifically inhibit GABA release from PV terminals and therefore, further support the idea that MORs contribute to homeostasis in CA1 neuro-circuit.

KW - GABA

KW - Hippocampus

KW - Mu opioid receptors

KW - Optogenetics

KW - Parvalbumin

KW - Whole-cell recordings

UR - https://www.scopus.com/pages/publications/85076249365

U2 - 10.1016/j.bbrc.2019.12.013

DO - 10.1016/j.bbrc.2019.12.013

M3 - 文章

C2 - 31818459

AN - SCOPUS:85076249365

SN - 0006-291X

VL - 522

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EP - 1062

JO - Biochemical and Biophysical Research Communications

JF - Biochemical and Biophysical Research Communications

IS - 4

ER -

Mu opioid receptors inhibit GABA release from parvalbumin interneuron terminals onto CA1 pyramidal cells

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