TY - JOUR
T1 - MXene-Ti3C2/CuS nanocomposites
T2 - Enhanced peroxidase-like activity and sensitive colorimetric cholesterol detection
AU - Li, Yapeng
AU - Kang, Z.
AU - Kong, Lingyao
AU - Shi, Huiting
AU - Zhang, Yanzhou
AU - Cui, M.
AU - Yang, Da Peng
N1 - Publisher Copyright:
© 2019 Elsevier B.V.
PY - 2019/11
Y1 - 2019/11
N2 - Nanomaterials with enzyme-like activity have attracted much attention recently. Herein, we report the synthesis of a new type of 2D MXene-Ti3C2/CuS nanocomposites with peroxidase-like activity using a simple hydrothermal approach. Significantly, compared with the individual MXene-Ti3C2 nanosheets or CuS nanoparticles, the MXene-Ti3C2/CuS nanocomposites show a synergistically enhanced peroxidase-like activity and can be used as an efficient mimetic peroxidase to catalyze the reaction of 3,3,5,5-tetramethylbenzidine (TMB) in the presence of hydrogen peroxide (H2O2), causing a blue color change. Kinetic studies reveal that the MXene-Ti3C2/CuS nanocomposites have a higher catalytic activity to TMB than their single components, and the catalytic reaction follows the ping-pong mechanism. The MXene-Ti3C2/CuS nanocomposites are used for the colorimetric determination of cholesterol with a linear range of 10–100 μM and a limit of detection (LOD) of 1.9 μM. Our results show that the MXene-Ti3C2/CuS nanocomposites based colorimetric cholesterol biosensor is cost-effective, sensitive, and selective, which has potential application in H2O2 and cholesterol detection and clinic medicine diagnostics.
AB - Nanomaterials with enzyme-like activity have attracted much attention recently. Herein, we report the synthesis of a new type of 2D MXene-Ti3C2/CuS nanocomposites with peroxidase-like activity using a simple hydrothermal approach. Significantly, compared with the individual MXene-Ti3C2 nanosheets or CuS nanoparticles, the MXene-Ti3C2/CuS nanocomposites show a synergistically enhanced peroxidase-like activity and can be used as an efficient mimetic peroxidase to catalyze the reaction of 3,3,5,5-tetramethylbenzidine (TMB) in the presence of hydrogen peroxide (H2O2), causing a blue color change. Kinetic studies reveal that the MXene-Ti3C2/CuS nanocomposites have a higher catalytic activity to TMB than their single components, and the catalytic reaction follows the ping-pong mechanism. The MXene-Ti3C2/CuS nanocomposites are used for the colorimetric determination of cholesterol with a linear range of 10–100 μM and a limit of detection (LOD) of 1.9 μM. Our results show that the MXene-Ti3C2/CuS nanocomposites based colorimetric cholesterol biosensor is cost-effective, sensitive, and selective, which has potential application in H2O2 and cholesterol detection and clinic medicine diagnostics.
KW - Cholesterol
KW - Colorimetric detection
KW - CuS
KW - MXene
KW - TiC
UR - https://www.scopus.com/pages/publications/85069706833
U2 - 10.1016/j.msec.2019.110000
DO - 10.1016/j.msec.2019.110000
M3 - 文章
C2 - 31499984
AN - SCOPUS:85069706833
SN - 0928-4931
VL - 104
JO - Materials Science and Engineering C
JF - Materials Science and Engineering C
M1 - 110000
ER -