TY - JOUR
T1 - NPR-C gene polymorphism is associated with increased susceptibility to coronary artery disease in Chinese Han population
T2 - A multicenter study
AU - Hu, Qin
AU - Liu, Qiji
AU - Wang, Shasha
AU - Zhen, Xi
AU - Zhang, Zhimian
AU - Lv, Ruijuan
AU - Jiang, Guihua
AU - Ma, Zhiyong
AU - He, Hong
AU - Li, Daqing
AU - Liu, Xiaoling
AU - Gao, Fei
AU - Li, Jifu
AU - Li, Li
AU - Zhang, Mei
AU - Ji, Xiaoping
AU - Chen, Yuguo
AU - Wang, Daowen
AU - Huang, Dejia
AU - Ma, Aiqun
AU - Huang, Wei
AU - Zhao, Yuxia
AU - Gong, Yaoqin
AU - Zhang, Cheng
AU - Zhang, Yun
PY - 2016/6/7
Y1 - 2016/6/7
N2 - To find a new locus that confers significant susceptibility to CAD in Chinese Han population, a genome-wide association study in 200 "extreme individuals" from a Shandong cohort and a pathway-based candidate gene study from a Shanghai cohort (293 CAD/293 controls) were simultaneously performed. Amongst them, 13 SNPs associated with CAD were selected to conduct validation and replication studies in additional 3363 CAD patients and 3148 controls. A novel locus rs700926 in natriuretic peptide receptor C (NPR-C) was identified in Shandong and Hubei cohorts. Then rs700926 and other nine tag SNPs were genotyped in four geographically different populations (Shandong, Shaanxi, Hubei and Sichuan cohorts), and 6 SNPs (rs700926, rs1833529, rs2270915, rs17541471, rs3792758 and rs696831) showed stronger association with CAD, regardless of single or combined analysis. We further genotyped rs2270915 and 10 additional tag SNPs in a central China cohort and identified rs12697273 and rs10066436 as the loci associated with CAD. All these positive associations remained significant after adjustment for traditional risk factors of CAD. NPR-C gene SNPs significantly contribute to CAD susceptibility in the Chinese Han population.
AB - To find a new locus that confers significant susceptibility to CAD in Chinese Han population, a genome-wide association study in 200 "extreme individuals" from a Shandong cohort and a pathway-based candidate gene study from a Shanghai cohort (293 CAD/293 controls) were simultaneously performed. Amongst them, 13 SNPs associated with CAD were selected to conduct validation and replication studies in additional 3363 CAD patients and 3148 controls. A novel locus rs700926 in natriuretic peptide receptor C (NPR-C) was identified in Shandong and Hubei cohorts. Then rs700926 and other nine tag SNPs were genotyped in four geographically different populations (Shandong, Shaanxi, Hubei and Sichuan cohorts), and 6 SNPs (rs700926, rs1833529, rs2270915, rs17541471, rs3792758 and rs696831) showed stronger association with CAD, regardless of single or combined analysis. We further genotyped rs2270915 and 10 additional tag SNPs in a central China cohort and identified rs12697273 and rs10066436 as the loci associated with CAD. All these positive associations remained significant after adjustment for traditional risk factors of CAD. NPR-C gene SNPs significantly contribute to CAD susceptibility in the Chinese Han population.
KW - Coronary artery disease
KW - Genome-wide association studies
KW - Natriuretic peptide receptor C
KW - Pathology Section
KW - Single nucleotide polymorphisms
KW - Susceptibility gene
UR - https://www.scopus.com/pages/publications/84973620800
U2 - 10.18632/oncotarget.9358
DO - 10.18632/oncotarget.9358
M3 - 文章
C2 - 27191271
AN - SCOPUS:84973620800
SN - 1949-2553
VL - 7
SP - 33662
EP - 33674
JO - Oncotarget
JF - Oncotarget
IS - 23
ER -