Research advances in the relationship between nonalcoholic fatty liver disease and atherosclerosis

Xin Xu; Linlin Lu; Quanyong Dong; Xiaolin Li; Nannan Zhang; Yongning Xin; Shiying Xuan

doi:10.1186/s12944-015-0141-z

Research advances in the relationship between nonalcoholic fatty liver disease and atherosclerosis

Xin Xu
, Linlin Lu
, Quanyong Dong
, Xiaolin Li
, Nannan Zhang
, Yongning Xin
, Shiying Xuan

Dalian Medical University
Digestive Disease Key Laboratory of Qingdao
Qingdao Municipal Hospital

科研成果: 期刊稿件 › 文献综述 › 同行评审

56 引用（Scopus）

摘要

Nonalcoholic fatty liver disease (NAFLD) is a metabolic stress-induced liver disease that is closely related not only to genetic susceptibility but also to insulin resistance and highly linked with metabolic syndrome. In recent years, the prevalence of NAFLD has increased rapidly, paralleling the epidemic of type 2 diabetes mellitus and obesity leading to cardiovascular disease. It has been demonstrated that NAFLD is highly associated with atherosclerosis. With recently gained knowledge, it appears that NAFLD may induce insulin resistance, dyslipidemia, oxidative stress, inflammation, and fluctuation of adipokines associated with atherosclerosis. In this review, we aimed to summarize recent discoveries related to both NAFLD and atherosclerosis, and to identify possible mechanisms linking them.

源语言	英语
文章编号	158
期刊	Lipids in Health and Disease
卷	14
期	1
DOI	https://doi.org/10.1186/s12944-015-0141-z
出版状态	已出版 - 3 12月 2015
已对外发布	是

联合国可持续发展目标

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可持续发展目标 3 良好健康与福祉

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title = "Research advances in the relationship between nonalcoholic fatty liver disease and atherosclerosis",

abstract = "Nonalcoholic fatty liver disease (NAFLD) is a metabolic stress-induced liver disease that is closely related not only to genetic susceptibility but also to insulin resistance and highly linked with metabolic syndrome. In recent years, the prevalence of NAFLD has increased rapidly, paralleling the epidemic of type 2 diabetes mellitus and obesity leading to cardiovascular disease. It has been demonstrated that NAFLD is highly associated with atherosclerosis. With recently gained knowledge, it appears that NAFLD may induce insulin resistance, dyslipidemia, oxidative stress, inflammation, and fluctuation of adipokines associated with atherosclerosis. In this review, we aimed to summarize recent discoveries related to both NAFLD and atherosclerosis, and to identify possible mechanisms linking them.",

keywords = "Atherosclerosis, Cardiovascular disease, Insulin resistance, Metabolic syndrome, Nonalcoholic fatty liver disease",

author = "Xin Xu and Linlin Lu and Quanyong Dong and Xiaolin Li and Nannan Zhang and Yongning Xin and Shiying Xuan",

note = "Publisher Copyright: {\textcopyright} 2015 Xu et al.",

year = "2015",

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day = "3",

doi = "10.1186/s12944-015-0141-z",

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TY - JOUR

T1 - Research advances in the relationship between nonalcoholic fatty liver disease and atherosclerosis

AU - Xu, Xin

AU - Lu, Linlin

AU - Dong, Quanyong

AU - Li, Xiaolin

AU - Zhang, Nannan

AU - Xin, Yongning

AU - Xuan, Shiying

PY - 2015/12/3

Y1 - 2015/12/3

N2 - Nonalcoholic fatty liver disease (NAFLD) is a metabolic stress-induced liver disease that is closely related not only to genetic susceptibility but also to insulin resistance and highly linked with metabolic syndrome. In recent years, the prevalence of NAFLD has increased rapidly, paralleling the epidemic of type 2 diabetes mellitus and obesity leading to cardiovascular disease. It has been demonstrated that NAFLD is highly associated with atherosclerosis. With recently gained knowledge, it appears that NAFLD may induce insulin resistance, dyslipidemia, oxidative stress, inflammation, and fluctuation of adipokines associated with atherosclerosis. In this review, we aimed to summarize recent discoveries related to both NAFLD and atherosclerosis, and to identify possible mechanisms linking them.

AB - Nonalcoholic fatty liver disease (NAFLD) is a metabolic stress-induced liver disease that is closely related not only to genetic susceptibility but also to insulin resistance and highly linked with metabolic syndrome. In recent years, the prevalence of NAFLD has increased rapidly, paralleling the epidemic of type 2 diabetes mellitus and obesity leading to cardiovascular disease. It has been demonstrated that NAFLD is highly associated with atherosclerosis. With recently gained knowledge, it appears that NAFLD may induce insulin resistance, dyslipidemia, oxidative stress, inflammation, and fluctuation of adipokines associated with atherosclerosis. In this review, we aimed to summarize recent discoveries related to both NAFLD and atherosclerosis, and to identify possible mechanisms linking them.

KW - Atherosclerosis

KW - Cardiovascular disease

KW - Insulin resistance

KW - Metabolic syndrome

KW - Nonalcoholic fatty liver disease

UR - https://www.scopus.com/pages/publications/84949671299

U2 - 10.1186/s12944-015-0141-z

DO - 10.1186/s12944-015-0141-z

M3 - 文献综述

C2 - 26631018

AN - SCOPUS:84949671299

SN - 1476-511X

VL - 14

JO - Lipids in Health and Disease

JF - Lipids in Health and Disease

IS - 1

M1 - 158

ER -

Research advances in the relationship between nonalcoholic fatty liver disease and atherosclerosis

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