TY - JOUR
T1 - Rethinking IRPs/IRE system in neurodegenerative disorders
T2 - Looking beyond iron metabolism
AU - Yao, Zhengyang
AU - Fu, Lin
AU - Jia, Fengju
AU - Bi, Mingxia
AU - Jiao, Qian
AU - Chen, Xi
AU - Du, Xixun
AU - Jiang, Hong
N1 - Publisher Copyright:
© 2021
PY - 2022/1
Y1 - 2022/1
N2 - Iron regulatory proteins (IRPs) and iron regulatory element (IRE) systems are well known in the progression of neurodegenerative disorders by regulating iron related proteins. IRPs are also regulated by iron homeostasis. However, an increasing number of studies have suggested a close relationship between the IRPs/IRE system and non-iron-related neurodegenerative disorders. In this paper, we reviewed that the IRPs/IRE system is not only controlled by iron ions, but also regulated by such factors as post-translational modification, oxygen, nitric oxide (NO), heme, interleukin-1 (IL-1), and metal ions. In addition, by regulating the transcription of non-iron related proteins, the IRPs/IRE system functioned in oxidative metabolism, cell cycle regulation, abnormal proteins aggregation, and neuroinflammation. Finally, by emphasizing the multiple regulations of IRPs/IRE system and its potential relationship with non-iron metabolic neurodegenerative disorders, we provided new strategies for disease treatment targeting IRPs/IRE system.
AB - Iron regulatory proteins (IRPs) and iron regulatory element (IRE) systems are well known in the progression of neurodegenerative disorders by regulating iron related proteins. IRPs are also regulated by iron homeostasis. However, an increasing number of studies have suggested a close relationship between the IRPs/IRE system and non-iron-related neurodegenerative disorders. In this paper, we reviewed that the IRPs/IRE system is not only controlled by iron ions, but also regulated by such factors as post-translational modification, oxygen, nitric oxide (NO), heme, interleukin-1 (IL-1), and metal ions. In addition, by regulating the transcription of non-iron related proteins, the IRPs/IRE system functioned in oxidative metabolism, cell cycle regulation, abnormal proteins aggregation, and neuroinflammation. Finally, by emphasizing the multiple regulations of IRPs/IRE system and its potential relationship with non-iron metabolic neurodegenerative disorders, we provided new strategies for disease treatment targeting IRPs/IRE system.
KW - Iron regulatory element (IRE)
KW - Iron regulatory proteins (IRPs)
KW - Neurodegenerative disorders
KW - Non-iron
UR - https://www.scopus.com/pages/publications/85118856049
U2 - 10.1016/j.arr.2021.101511
DO - 10.1016/j.arr.2021.101511
M3 - 文献综述
C2 - 34767973
AN - SCOPUS:85118856049
SN - 1568-1637
VL - 73
JO - Ageing Research Reviews
JF - Ageing Research Reviews
M1 - 101511
ER -