Sweet signaling for ferroptosis

Fan Yu; Lingyu Jiang; Quan Chen

doi:10.1016/j.chembiol.2025.08.012

Sweet signaling for ferroptosis

Fan Yu
, Lingyu Jiang
, Quan Chen

生命科学与健康学院

Nankai University

科研成果: 期刊稿件 › 评论/辩论

摘要

A recent study published in Nature Cell Biology by Zhang et al. has uncovered a critical role for O-GlcNAcylation in sensing and regulating ferroptosis.¹ Ferroptosis-induced ROS promotes OGT-mediated FOXK2 O-GlcNAcylation, driving its nuclear translocation to upregulate SLC7A11 and suppress cell death. This axis fuels HCC progression and therapy resistance, highlighting its therapeutic potential.

源语言	英语
页（从-至）	1097-1098
页数	2
期刊	Cell Chemical Biology
卷	32
期	9
DOI	https://doi.org/10.1016/j.chembiol.2025.08.012
出版状态	已出版 - 18 9月 2025

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10.1016/j.chembiol.2025.08.012

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title = "Sweet signaling for ferroptosis",

abstract = "A recent study published in Nature Cell Biology by Zhang et al. has uncovered a critical role for O-GlcNAcylation in sensing and regulating ferroptosis.1 Ferroptosis-induced ROS promotes OGT-mediated FOXK2 O-GlcNAcylation, driving its nuclear translocation to upregulate SLC7A11 and suppress cell death. This axis fuels HCC progression and therapy resistance, highlighting its therapeutic potential.",

author = "Fan Yu and Lingyu Jiang and Quan Chen",

note = "Publisher Copyright: {\textcopyright} 2025 Elsevier Ltd",

year = "2025",

month = sep,

day = "18",

doi = "10.1016/j.chembiol.2025.08.012",

language = "英语",

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T1 - Sweet signaling for ferroptosis

AU - Yu, Fan

AU - Jiang, Lingyu

AU - Chen, Quan

PY - 2025/9/18

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N2 - A recent study published in Nature Cell Biology by Zhang et al. has uncovered a critical role for O-GlcNAcylation in sensing and regulating ferroptosis.1 Ferroptosis-induced ROS promotes OGT-mediated FOXK2 O-GlcNAcylation, driving its nuclear translocation to upregulate SLC7A11 and suppress cell death. This axis fuels HCC progression and therapy resistance, highlighting its therapeutic potential.

AB - A recent study published in Nature Cell Biology by Zhang et al. has uncovered a critical role for O-GlcNAcylation in sensing and regulating ferroptosis.1 Ferroptosis-induced ROS promotes OGT-mediated FOXK2 O-GlcNAcylation, driving its nuclear translocation to upregulate SLC7A11 and suppress cell death. This axis fuels HCC progression and therapy resistance, highlighting its therapeutic potential.

UR - https://www.scopus.com/pages/publications/105015639250

U2 - 10.1016/j.chembiol.2025.08.012

DO - 10.1016/j.chembiol.2025.08.012

M3 - 评论/辩论

C2 - 40972519

AN - SCOPUS:105015639250

SN - 2451-9456

VL - 32

SP - 1097

EP - 1098

JO - Cell Chemical Biology

JF - Cell Chemical Biology

IS - 9

ER -

Sweet signaling for ferroptosis

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