Wnt 信号通路在外周 T 细胞淋巴瘤中的研究进展

As a rare and heterogeneous group of non⁃Hodgkin lymphomas, most of peripheral T⁃cell lymphomas (PTCL) are highly aggressive and usually do not respond well to chemotherapy. The research found that the disorder of canonical Wnt signaling pathway is involved in the pathogenesis of some subtypes of PTCL. Canonical Wnt signaling pathway plays an important role in the development and differentiation of T⁃lymphocytes and tumorigenesis. In recent years, exploring the relationship between canonical Wnt signaling pathway and the development of PTCL is expected to provide new ideas and targets for the treatment of PTCL.